Anna Faris and Regina Hall are back as the lovable, dim-witted Cindy Campbell and her self-serving, sex-crazed pal Brenda respectively. They are joined this time around by Craig Bierko as the cute, but utterly clueless, Tom Ryan. Together, they battle to save the world from a ruthless alien invasion. Cindy Campbell moves in next to Tom Ryan because she's taking care of an old lady. She finds out the house is haunted by a little boy and goes on a quest in the village to find out who killed him and why. Also, Alien "Tr-iPods" are invading the world and Cindy has to uncover the secret in order to stop them.